Chemical Biology:

Dr. Cao seeks to tackle important problems across a wide range of biomedical sciences including ion channel mechanism, protein-drug interaction, and cancer immunotherapy. 

2006—2010, B.S., Chemistry Department of Qufu Normal University

2010—2013, M.S., State Key Laboratory of Elemento-Organic Chemistry, Chemistry Department of Nankai University

2013—2017, Ph.D., State Key Laboratory of Elemento-Organic Chemistry, Chemistry Department of Nankai University

2014—2017, Joint-Ph.D., The Department of Biological Chemistry and Molecular Pharmacology, Harvard University Medical School

2017—2019, Postdoctoral Research Fellow, The Department of Biological Chemistry and Molecular Pharmacology, Harvard University Medical School

Dr. Cao has published Nature 2016, PNAS 2017, Advanced Science 2019 et al as first-author or co-first author in the last five years, and her scientific papers were cited by more than 360 times.

Five Representative Publication:

[1] Cao Chan; Wang Shuqing; Cui Tanxing; Su Xun Cheng*; Chou James J*; Ion

and inhibitor binding of the double-ring ion selectivity filter of the

mitochondrial calcium uniporter , Proceedings of the National Academy of

Sciences of the United States of America, 2017, 114(14): E2846-E2851. 

[2] Oxenoid, Kirill#; Dong, Ying#; Cao, Chan#; Cui, Tanxing#; Sancak,

Yasemin; Markhard, Andrew L.; Grabarek, Zenon; Kong, Liangliang; Liu, Zhijun;

Ouyang, Bo; Cong, Yao; Mootha, Vamsi K.; Chou, James J.*; Architecture of the

mitochondrial calcium uniporter , Nature, 2016, 533(7602): 269-273.

[3] Pan, Liqiang#; Cao, Chan#; Run, Changqing; Zhou, Liujuan; Chou, James J.*

; DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and

Tumor Killing , Advanced Science, 2020, 7(2): 1900973.

[4] Cao, Chan; Chen, Jia-Liang; Yang, Yin; Huang, Feng; Otting, Gottfried;

Su, Xun-Cheng*; Selective N-15-labeling of the side-chain amide groups of

asparagine and glutamine for applications in paramagnetic NMR spectroscopy , J

ournal of Biomolecular NMR, 2014, 59(4): 251-261.

[5] Yuan, Yuan#; Cao, Chan#; Wen, Maorong; Li, Min; Dong, Ying; Wu, Lijie;

Wu, Jian; Cui, Tanxing; Li, Dianfan*; Chou, James J.*; OuYang, Bo*; Structural

Characterization of the N-Terminal Domain of the Dictyostelium discoideum

Mitochondrial Calcium Uniporter , ACS Omega, 2020, 5(12): 6452-6460.

Per year: 

two master graduates, two Ph.D. graduates