Dr. Cao seeks to tackle important problems across a wide range of biomedical sciences including ion channel mechanism, protein-drug interaction, and cancer immunotherapy.
2006—2010, B.S., Chemistry Department of Qufu Normal University
2010—2013, M.S., State Key Laboratory of Elemento-Organic Chemistry, Chemistry Department of Nankai University
2013—2017, Ph.D., State Key Laboratory of Elemento-Organic Chemistry, Chemistry Department of Nankai University
2014—2017, Joint-Ph.D., The Department of Biological Chemistry and Molecular Pharmacology, Harvard University Medical School
2017—2019, Postdoctoral Research Fellow, The Department of Biological Chemistry and Molecular Pharmacology, Harvard University Medical School
2019, Harvard Medical School CSSA Outstanding Leadership Award
Dr. Cao has published Nature 2016, PNAS 2017, Advanced Science 2019 et al as first-author or co-first author in the last five years, and her scientific papers were cited by more than 360 times.
Five Representative Publication:
 Cao Chan; Wang Shuqing; Cui Tanxing; Su Xun Cheng*; Chou James J*; Ion
and inhibitor binding of the double-ring ion selectivity filter of the
mitochondrial calcium uniporter , Proceedings of the National Academy of
Sciences of the United States of America, 2017, 114(14): E2846-E2851.
 Oxenoid, Kirill#; Dong, Ying#; Cao, Chan#; Cui, Tanxing#; Sancak,
Yasemin; Markhard, Andrew L.; Grabarek, Zenon; Kong, Liangliang; Liu, Zhijun;
Ouyang, Bo; Cong, Yao; Mootha, Vamsi K.; Chou, James J.*; Architecture of the
mitochondrial calcium uniporter , Nature, 2016, 533(7602): 269-273.
 Pan, Liqiang#; Cao, Chan#; Run, Changqing; Zhou, Liujuan; Chou, James J.*
; DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and
Tumor Killing , Advanced Science, 2020, 7(2): 1900973.
 Cao, Chan; Chen, Jia-Liang; Yang, Yin; Huang, Feng; Otting, Gottfried;
Su, Xun-Cheng*; Selective N-15-labeling of the side-chain amide groups of
asparagine and glutamine for applications in paramagnetic NMR spectroscopy , J
ournal of Biomolecular NMR, 2014, 59(4): 251-261.
 Yuan, Yuan#; Cao, Chan#; Wen, Maorong; Li, Min; Dong, Ying; Wu, Lijie;
Wu, Jian; Cui, Tanxing; Li, Dianfan*; Chou, James J.*; OuYang, Bo*; Structural
Characterization of the N-Terminal Domain of the Dictyostelium discoideum
Mitochondrial Calcium Uniporter , ACS Omega, 2020, 5(12): 6452-6460.
two master graduates, two Ph.D. graduates