Biological paramagnetic resonance

2003.09-2007.06 B.S. in Biotechnology, Department of Biology, Nankai University

2007.09-2010.06 M.S. in Cell Biology, Department of Biology, Nankai University

2012.09-2015.06 Ph.D. in Chemical Biology, Department of Chemistry, Nankai University 

2015.08-2019.08 Post-doctor, Department of Chemical and Biological Physics, Weizmann Institute of Science, Israel 

2020.04 - present Researcher, Department of Chemistry, Nankai University

She has made significant progresses on paramagnetic nuclear magnetic resonance spectroscopy and electron paramagnetic resonance based on spin probes. Her previous work involves both to important protein systems. The recent achievements include: 1) Development of a series of spin labeling agents and methods for probing the dynamics of biological macromolecules; 2) Development of high-resolution DEER distance measuring methods for monitoring the conformation dynamics and interactions of proteins in the cells; 3) Characterization of the effect of the cellular environment on protein dimer stability and the conformation of its flexible domain via in-cell EPR methods. The results have been published on reputable academic journals including PNAS, Angew Chem, JPCL etc. 

(1) Yin Yang#; Shen-Na Chen#; Feng Yang; Xia-Yan Li; Akiva Feintuch; Xun-Cheng Su*; Daniella Goldfarb*; In-cell destabilization of a homodimeric protein complex detected by DEER spectroscopy, Proceedings of the National Academy of Sciences of the United States of America, 2020, 56: 2914-2918.

(2) Yin Yang; Bin-Bin Pan; Xiaoli Tan; Feng Yang; Yangping Liu*; Xun-Cheng Su*; Daniella Goldfarb*; In-Cell Trityl-Trityl Distance Measurements on Proteins, The Journal of Physical Chemistry Letters, 2020, 11: 1141-1147.

(3) Yin Yang; Feng Yang; Xia-Yan Li; Xun-Cheng Su*; Daniella Goldfarb*; In-cell EPR distance measurements on ubiquitin labeled with a rigid PyMTA-Gd(III) tag, The Journal of Physical Chemistry B, 2019, 123: 1050-1059. 3区

(4) Yin Yang#; Feng Yang#; Yan-Jun Gong; Thorsten Bahrenberg; Akiva Feintuch; Xun-Cheng Su*; Daniella Goldfarb*; High sensitivity in-cell EPR distance measurements on proteins using an optimized Gd(III) spin label, The Journal of Physical Chemistry Letters, 2018, 9: 6119-6123. 

(5) Yin Yang#; Feng Yang#; Yan-Jun Gong; Jia-**********; Daniella Goldfarb*; Xun-Cheng Su*; A reactive, rigid Gd(III) labeling tag for in-cell EPR distance measurements in proteins, Angewandte Chemie International Edition, 2017, 56: 2914-2918.