C-H Functionalization, Total Synthesis

1999-2003 BS, Nankai University

2003-2009 PhD, Shanghai Institute of Organic Chemistry

2010-2014 Postdoctoral, The Pennsylvania State University, USA

2015-present State Key Laboratory of Elemento-Organic Chemistry, Nankai University

1. Total Synthesis of Hibispeptin A via Pd-Catalyzed C(sp3)?H Arylation with Sterically Hindered Aryl Iodides. Gang He, Shuyu Zhang, William A. Nack, Ryan Pearson, Javon Rabb-Lynch, and Gong Chen*. Org. Lett. 2014. 16, 6488-6491.

2. Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated g C(sp3)-H Bonds. Gang He, Shu-Yu Zhang, William A. Nack, and Gong Chen*. Angew. Chem. Int. Ed. 2013, 52, 11124-11128. 

3. An Improved Protocol for Indoline Synthesis via Palladium-Catalyzed Intramolecular C(sp2)-H Amination. Gang He, Chengxi Lu, Yingsheng Zhao, William A. Nack, and Gong Chen*. Org. Lett. 2012, 14, 2945-2947. 

4. Highly Efficient Syntheses of Azetidines, Pyrrolidines and Indolines via Palladium-Catalyzed Intramolecular Amination of C(sp3) and C(sp2)-H Bonds at gamma and delta Positions. Gang He, Yingsheng Zhao, Shuyu Zhang, Chengxi Lu, and Gong Chen*. J. Am. Chem. Soc. 2012, 134, 3-6. 

5. A Practical ******** for Structural Diversification of Aliphatic Scaffolds via Pd-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)-H Bonds. Gang He and Gong Chen*. Angew. Chem. Int. Ed. 2011, 50, 5192-5196.