1) Studies on the design, synthesis and Biological evaluation of bio-active natural product analogs

2) New methodology for organic synthesis and natural products;

1990 B.S.in Industrial Analysis, Beijing University of Chemical Technology

1990 — 2000 Quality Control Engineer (Tianjin Chemical Plant, PR China)

2000 — 2005 Ph. D. degree in Agro-chemistry, Research Institute of Elemento-Organic Chemistry of Nankai University

2005 —2024  Associate Professor, Nankai University

2024-12— Professor, Nankai University

1. J. Y. Zhou, L. H. Chen, Ziang Miao, J. J. Li, Y. X. Luan,* L. Chen,* P. P. Tang*, Photocatalyst-Regulated Trifluoromethoxylation of Aryl Halides under Silver Promotion, J. Am. Chem. Soc., 2025, 147, 38979−38986. 

2. P. F. Yang, S. H. Chen, J. X. Lu, P. F. Ning, W. Q. Zhao, Y. X. Luan, L. Chen,* X. F. Xu,* P. P. Tang*, Silver-Catalyzed syn-Stereoselective Trifluoromethoxylation of Bicyclo[1.1.0]butanes, Org. Lett. 2025, 27, 7679−7684 

3. I. Djavani-Tabrizi, Z. Q. Yuan, T. T. Lindkvist, J. M. Xing, L. Chen,* S. B. Nielsen*, Gas-Phase Fluorescence Excitation Experiments on Cryogenically Cold Rhodamine B Cations Linked to Various Amino Acid Esters, J. Am. Soc. Mass Spectrom. 2025, 36, 409−415. 

4. Catalytic Asymmetric Reactions of Ketimines and Alkenes via [2+2] Cy-cloaddition: Chemical Reactivity Controlled by Switching a Heteroatom, Q. Zhao, Y. Li, Z. Y. Ren, Y. B. Shao, L. Chen*, X. Li*, J. Am. Chem. Soc., 2024, 146, 32088-32097

5. Silver-Enabled Dearomative Trifluoromethoxylation of Indoles, Z. J. Deng, L. D. Meng, X. Bing, S. X. Niu, X. F. Zhang, J. Q. Peng, Y. X. Luan, L. Chen*, P. P. Tang*, J. Am. Chem. Soc., 2024, 146, 2325-2332.

6. Enantioselective Synthesis of “NO2···NH” Hydrogen Bond-Stabilized C–N Axially Chiral Diarylamines, W. Lin, Y. B. Shao, Z. Y. Hao, Z. L. Huang, Z. Y. Ren, L. Chen*, X. Li*, ACS Catalysis, 2024, 14, 1183-1192.

7. Predicting bond dissociation energies of cyclic hypervalent halogen reagents using DFT calculations and graph attention network model, Y. Shao, Z. Ren, Z. Han, L. Chen*, Y. Li*, X. Xue*, Beilstein J. Org. Chem. 2024, 20, 1444–1452.

8. Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C6F5)3/chiral phosphoric acid, Z. Liu, Z. Y. Ren, C. Yang, X. Y. Shao, L. Chen*, X. Li*, Chin. Chem. Lett., 2023, 108939.

9. Asymmetric Synthesis of Axially Chiral Arylpyrazole via an Organocatalytic Arylation Reaction, X. Gao, C. W. Li, L. Chen*, X. Li*, Org. Lett., 2023, 25, 7628- 7632. 

10. Synthesis and Biological Activity of Lycorine Derivatives Containing Malate Ester, Y. Zhao, L. Qiao, G. F. Zhao, L. Chen*, Chem. J. Chinese Uni., 2021, 42, 2789-2797.

11. Triangular rhodamine triads and their intrinsic photophysics revealed from gas-phase ion fluorescence experiments, Y. Zhao, E. R. Sørensen, T. T. Lindkvist, C. Kjær, M. B. Nielsen, L. Chen*, S. B. Nielsen*, Chem. Eur. J. 2021, 27, 10875–10882.

12. Gas-phase Förster resonance energy transfer in mass-selected ions with methylene or peptide linkers between two dyes: a concerted dance of charges, C. Kjær, Y. Zhao, M. H. Stockett, L. Chen*, K. Hansen*, S. B. Nelsen*, Phys. Chem. Chem. Phys, 2020, 22, 11095-11100.