Organic Chemistry

Organic Phosphorus Chemistry:

Synthesis of organic functional phosphorus compounds which have biological activities.

Asymmetric Synthesis and Organic Synthesis Chemistry:

Our efforts in this area mainly emphasize the development new asymmetric synthesis reactions and catalysts, which greatly benefit practicing synthetic organic chemists.

B. S. (1987-1991), Tianjin Normal University, China (Major: Chemistry)

M.S. (1994-1998), Tianjin Normal University, China (Major: Physical Chemistry)

Ph. D. (1999-2002), Tsinghua University, China (Major: Organic Chemistry)

Post-doctor (2002-2004), ETH Zürich, Switzerland (Major: Organic Chemistry)

Professional Activities:

1991—1994 Assistant Professor in Tianjin Normal University

1998-1999 Lecturer in Tianjin Normal University

2002—2004 Post-doctor in ETH Zürich, Switzerland

2004—2011 Associate Professor in Institute of Elemento-Organic Chemistry, Nankai University

2012—now Full Professor in Institute of Elemento-Organic Chemistry, Nankai University

Up to now, I've published more than 60 academic papers and applied 5 patents

Selected Publications

1. Yuming Li, Haikun Zhang, Rong Wei and Zhiwei Miao* “Chemo- and Diastereoselective Construction of Indenopyrazolines via a Cascade aza-Michael/Aldol Annulation of Huisgen Zwitterions with 2-Arylideneindane-1,3-diones” Adv. Synth. Catal. 2017, DOI: 10.1002/adsc.201701013.

2. Yan Cai, Hairong Lyu, Chengbin Yu, Zhiwei Miao* “Unexpected Stereoselectivity Synthesis of (Z)-β-Alkenyl Substituted β-Amino Phosphonates Through β,γ-Dihydrogen Shift Reaction Catalyzed by [Cu(MeCN)4]PF6/I2”Adv. Synth. Catal. 2014, 356, 596-602.

3. Gang Hou, Jipan Yu, Chengbin Yu, Guiping Wu, Zhiwei Miao* “Enantio- and Diastereoselective Vinylogous Mukaiyama Aldol Reactions of α-Keto phosphonates with 2-(Trimethylsilyloxy)furan Catalyzed by Bis(oxazoline)-copper Complexes” Adv. Synth. Catal. 2013, 355, 589-593.

4. Shasha Kong, Weidong Fan, Guiping Wu, Zhiwei Miao* “Enantioselective Synthesis of Tertiary α-Hydroxy Phosphonates Catalyzed by Carbohydrate/Cinchona Alkaloid Thiourea Organocatalysts” Angew. Chem. Int. Ed. 2012, 51, 8864-8867.

5. Yangyun Wang, Haitao Yang, Jipan Yu, Zhiwei Miao,* and Ruyu Chen* “Highly Enantioselective Biginelli Reaction Promoted by Chiral Bifunctional Primary Amine-Thiourea Catalysts: Asymmetric Synthesis of Dihydropyrimidines” Adv. Synth. Catal. 2009, 351, 3057-3062.

6. Yadan Wang, Yangyun Wang, Jipan Yu, Zhiwei Miao,* and Ruyu Chen* “Stereoselective Synthesis of α-Amino(phenyl)methyl(phenyl)Phosphinic Acids with O-Pivaloylated D-Galactosylamine as Chiral Auxiliary” Chem. Eur. J. 2009, 15, 9290-9293.

7. Fei Wang, Yadan Wang, Lingchao Cai, Zhiwei Miao,* and Ruyu Chen “Efficient Syntheses of (Thio)phosphonylated Isobenzofurans by Tandem Nucleophilic Addition and Regioselective 5-Exo-dig Addition to Carbon-Carbon Triple Bond: Cooperative Effect to DBU” Adv. Synth. Catal. 2008, 350, 2733-2739.

8. Yadan Wang, Fei Wang, Yangyun Wang, Zhiwei Miao,* and Ruyu Chen “Glycosylation-Induced and Lewis Acid Catalyzed Asymmetric Synthesis of β-N-Glycosidically Linked α-Aminophosphonic Acids Derivatives” Adv. Synth. Catal. 2008, 350, 2339-2344.