Wang Liang, associate professor, Institute of Elemento-organic Chemistry, graduated from Nankai University.

Special Talent：

1. Total Synthesis of Natural Products

2. Medicinal Chemistry of Anti-Cancer Natural Products

3. Target Identification of Complex Natural Products 

2007-2011 B.S. from Shandong University, Shandong Province, P. R. China;

2011-2016 Ph. D. from Nankai University, P. R. China;

2016-2018.12: Lecturer at College of Pharmacy, Nankai University, Tianjin, P. R. China;

2018.12- 2020.10: Associate Prof. at College of Pharmacy, Nankai University, Tianjin, P. R. China;

2020.10-Present: Associate Prof. at College of Chemistry, Nankai University, Tianjin, P. R. China;

Prof. Wang Liang focus on the total synthesis of complex natural products, medicinal chemistry and target exploration based on natural products. He has guided students to complete the total synthesis of 21 complex natural products, and provided a number of small molecular entities for the in vivo animial experiments (renal fibrosis, pancreatic cancer, liver cancer, colon cancer, and acute lung injury). One anti-renal fibrosis candidate compound has been approved for Phase I clinical ethics and enrolled in Phase I clinical trials. Meanwhile, employing natural products as templates and based on structure-activity relationships, Prof. Wang designed several bioactive probes, which provided molecular tools for exploring new targets.

1. Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang,* Yue Chen.* A Two-phase Approach to Fusicoccane Synthesis to Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells. Angew. Chem. Int. Ed. 2022, 61, e202117476.

2. Jianshuang Guo, Juanjuan Li, Zehan Wang, ********, Yuxin Yue, Huabin Li, Xiuhe Zhao, Yuanjun Sun, Yahui Ding, Fei Ding, Dongsheng Guo,* Liang Wang,* Yue Chen. Dual Hypoxia-Responsive Supramolecular Complex for Cancer Target Therapy. Nat. Comm. 2023, 14, 5634.

3. Sen Zhang, Songming Zhang, Yunlong Fan, Xuhan Zhang, Jing Chen, Chaofan Jin, Sisi Chen, Liang Wang,* Quan Zhang,* Yue Chen.* Total Synthesis of the Proposed Structure of Neaumycin B. Angew. Chem. Int. Ed. 2023, e202313186.

4. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang,* Yue Chen.* Ovatodiolides: Scalable Protection-Free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2019, 58, 10587-10590.

5. Can Liu, Liang Wang,* Yuanjun Sun, Xiuhe Zhao, Tianyang Chen, Xiuwen Su, Hui Guo, Qin Wang, Xiaonan Xi, Yahui Ding,* Yue Chen.* Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angew. Chem. Int. Ed. 2022, 61, e202206953.

6. Yuanjun Sun#, Yahui Ding#, Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang,* Yue Chen.* Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2017, 56, 14627-14631.

7. Liang Wang, Hengtao Wang, Yi Hang Li, and Pingping Tang.* Total Synthesis of Schilancitrilactones B and C. Angew. Chem. Int. Ed. 2015, 54, 5732. 

8. Bolin Chen, Xijing Zhang, Yufen Yang, Dongdong Xu, Qianwei Wu, Shibo Wang, Shiqi Bao, Xuemei Zhang, Yahui Ding,* Liang Wang,* Yue Chen.* Hypocretenolides: Collective Total Syntheses and Activities toward Metastatic Colon Cancer, Chem. Sci. 2024, 15, 6397-6401.

9. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li,* Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, ********, Qiang Fu, Liang Wang,* Yue Chen.* Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J. Med. Chem. 2022, 65, 2971-2987.

10. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang,* Guang Yang,* Yue Chen.* Total Syntheses and Biological Activities of Vinylamycin Analogs. J. Med. Chem. 2017, 60, 1189-1209.

11. Bolin Chen, Yufen Yang, Xijing Zhang, Dongdong Xu, Yuanjun Sun,* Yue Chen,* Liang Wang.* Total Syntheses of Brassicicenes A, R, and T. Org. Lett. 2023, 25, 8570-8574.

12. Junhong Xiang, Xiuhe Zhao, Jiaxin Li, Yahui Ding,*, Chao Wang, Liang Wang,* Yue Chen.* Rapid Construction of the Scaffold of Quorumolide A Enabled by a Tandem ROM/RCM ******** and a Tandem Oxidative Cyclization ********. Org. Lett. 2023, 21, 6485-6487.

13. Junhong Xiang, Xuemei Zhang, Dehong Wang, Jiaxin Li, Qiuying Li, Qin Wang, Yahui Ding,* Tianyang Chen, Yuanjun Sun, Shiqi Bao, Jing Chen, Dongmei Li, Liang Wang,* Yue Chen.* Chemical Modification of Ovatodiolide Revealed A Promising Amino-Prodrug with Improved Pharmacokinetic Profile. Chem. Commun. 2020, 56,11018-11021.

14. Fangzhi Han, Guangju Liu, Chaofan Jin, Jinghan Wang, Jianwei Liu, Liang Wang,* and Yue Chen.* Total Synthesis and Determination of the Absolute Configuration of Rakicidin C. Org. Lett. 2021, 23, 7069-7073.

15. Fangzhi Han, Guangju Liu, Xiuhe Zhao, Shunshun Du, Yahui Ding, Quan Zhang, Huiting Deng, Liang Wang 

*, Yue Chen. Total Synthesis and Stereochemical Assignment of Rakicidin F. Org. Biomol. Chem., 2022, 20, 4135-4140.

16. Xiuhe Zhao, Mengxue Lv, Xiaonan Xi, Yaxin Lu, Liang Wang,* Yue Chen.* Synthesis of Anti-Pancreatic Cancer Natural Product Majusculamide D and Analogues Reveals a Preliminary Structure-Activity Relationships. Chin. J. Chem. 2024, 42, 605-610.

17. Da Wang, Chao Wang, Liang Wang* , Yue Chen*. A Comprehensive Review in Improving Delivery of Small-Molecule Chemotherapeutic Agents Overcoming the Blood-Brain/Brain Tumor Barriers for Glioblastoma Treatment. Drug Delivery 2019, 26, 551-565.

18. Baijun Ye, Peng Jiang, Tingrong Zhang, Yahui Ding, Yuanjun Sun, Xin Hao, Lanshu Li, Liang Wang,* Yue Chen.* Total Synthesis of the Highly N-Methylated Peptide Jahanyne. J. Org. Chem. 2018, 83, 6741-6747.

19. Yuanjun Sun , Xiuwen Su, Ruifei Zhou, Dehong Wang, Yuan Zhao, Yuhang Jiang, Liang Wang,* Yue Chen.* Total Synthesis of BE-43547A2. Tetrahedron 2018,74, 5955-5964.

20. Yuanjun Sun, Ruifei Zhou, Honglei Xu, Dehong Wang, Xiuwen Su, Chao Wang, Yahui Ding, Liang Wang,* Yue Chen.* Syntheses and Biological Evaluation of BE-43547A2 Analogues Modified at O35 Ester and C15-OH Sites. Tetrahedron 2018,75, 1808-1818.