Yuan Zhi

Yuan Zhi
Doctor professor 
Yuan Zhi, Doctor degree, professor, Institute of Polymer Science, graduated from Nankai University.
Special Talent:

Address: Room 512, Mong Man Wei Building, Nankai University, No. 94, Weijin Road, Tianjin, Peoples R China 

Telephone: 022-23501164

Email: zhiy@nankai.edu.cn
Research Interest: 1. Biomaterials in polymer: especially focuses on intelligent targeting drug/gene delivery system and bioimage regent;
2. Molecular recognition and interaction mechanism: especially focuses on functional polymer materials for adsorption/separation and R&D of peptide drugs

Recruiting disciplines: Chemistry, Chemical Engineering,Materials

=-Education and Working Experience-=:
1979-1983 B.S., Department of Chemistry, Nankai University
1983-1986 M.S., Institute of Polymer Chemistry, Nankai University
1986-1989 Ph. D., Institute of Polymer Chemistry, Nankai University
1989-1992 Lecturer, Institute of Polymer Chemistry, Nankai University
1992-1996 Associate professor, Institute of Polymer Chemistry, Nankai University
1996- Professor, Institute of Polymer Chemistry, Nankai University
2000-2004 Director of Institute of Polymer Chemistry, College of Chemistry, Nankai University
2000-2013 Vice-dean of College of Chemistry, Nankai University
2013- Chairman of the Degree Assess Committee of Polymer Chemistry; member of the academic committee of college of chemistry

Honors and Awards

Winner of Trans-Century Training Programme Foundation for the Talents by the State Education Commission
Winner of the first level of Tianjin 131 Project
Won the Third Prize of Young Chemistry of Chinese Chemical Society, the Third Youth Science and Technology Award of Tianjin, the Second Prize of Science and Technology Progress of Tianjin, the Third Prize of Science and Technology Progress of Ministry of Education, the Dupont Prize for Science and Technology Innovation of Ministry of Science and Technology, and the Second Prize of National Science and Technology Progress (2009)
Won the title of advanced women workers

Scientific Achievements & Selected Publications

1. More than 100 scientific papers have been published in peer-reviewed journals including Biomaterials, Biomacromolecules; 9 Chinese invention patents and 2 United States patents have been authorized.

2. Second Class Prizes of the State Science and Technology Advancement Award;Outstanding Young Chemist Award of Chinese Chemical Society; Young Science and Technology Award, Tianjin Science Society; Dupont Innovation Award from Ministry of Science and Technology; Third Class Award of Science and Technology Progress from Ministry of Education of China.

3. Winner of the National Advanced Female Workers, the first level of Tianjin 131 Project, and the Trans-Century Training Programme Foundation for the Talents by the State Education Commission(1999); Fixed member of Collaboration Innovation Center of Chemical Science and Engineering(Tianjin).

Representative papers are as follows:
[1] Zhi Yuan*, Reversible shielding between dual ligands for enhanced tumor accumulation of ZnPc-loaded micelles, Nano letter, 2019, 19 (3): 1665-1674.
[2] Zhi Yuan*, Fluorescence-enhanced covalent organic framework nanosystem for tumor imaging and photothermal therapy. Nanoscale, 2019, 11 (21): 10429-10438.
[3] Zhi Yuan*, Multivalent nanoparticles for personalized theranostic based on
tumor receptor distribution behavior, Nanoscale, 2019, 11 (11): 5005-5013.
[4] Zhi Yuan*, Near-infrared-light induced nanoparticles with enhanced tumor tissue penetration and intelligent drug release. Acta Biomaterialia 2019, 90: 314-323.
[5] Zhi Yuan*, A glutathione responsive nitric oxide release system based on charge-reversal chitosan nanoparticles for enhancing synergistic effect against multidrug resistance tumor. Nanomedicine 2019, 20, 102015.
[6] Zhi Yuan*, One-pot synthesis of acid-induced in situ aggregating theranostic gold nanoparticles with enhanced retention in tumor cells. Biomaterials Science 2019, 7 (5): 2009-2022.
[7] Zhi Yuan*, Chitosan sulfate inhibits angiogenesis via blocking the VEGF/VEGFR2 pathway and suppresses tumor growth in vivo, Biomaterials Science, DOI:10.1039/C8BM01337C
[8] Zhi Yuan*, Study on the effectiveness of ligand reversible-shielding strategy in targeted delivery and tumor therapy, Acta Biomaterialia., 2019, 83:349–358
[9] Zhi Yuan*, A Conveniently Self-assembled Pt (IV) Conjugated Nanocarrier by the Character of Glycyrrhetinic Acid for Targeting Treatment of Hepatic Carcinoma, Nanomedicine: NBM,2019,15:153-163
[10] Zhi Yuan*, Convenient preparation of charge-adaptive chitosan nanomedicines for extended blood circulation and accelerated endosomal escape, Nano Research, 2018,11,8:4278-4292
[11] Zhi Yuan*,The Systematic Evaluation of Size-dependent Toxicity and Multi-time Biodistribution of Gold Nanoparticles,Colloids and Surfaces B: Biointerfaces. 2018, 167:260-266
[12] Zhi Yuan*, The effects of ligand valency and density on the targeting ability of multivalent nanoparticles based on negatively charged chitosan nanoparticles, Colloids and Surfaces B: Biointerfaces, 2018, 161:508-518
[13] Zhi Yuan*, pH-Sensitive Reversible Programmed Targeting ******** by the Self-Assembly/Disassembly of Gold Nanoparticles, ACS Applied Materials & Interfaces, 2017,9:16767-16777
[14] Zhi Yuan*, An Intelligent Re-Shieldable Targeting System for Enhanced Tumor Accumulation, Journal of Controlled Release, 2017,268:1–9
[15] Zhi Yuan*, The Study of a Bifunctional Aβ Aggregation Inhibitor with the Abilities of Anti-amyloid and Copper Chelation,Biomacromolecules,2016, 17 (2):661–668
[16] Zhi Yuan*, A tripeptide GGH as the inhibitor of copper-amyloid-β-mediated redox reaction and toxicity, ACS Chemical Neuroscience, 2016, 7 (9):1255–1263
[17] Zhi Yuan*, In Vitro Studies on Accelerating the Degradation and Clear-ance of Amyloid-β Fibrils by an Anti-amyloidogenic Peptide, ACS Macromolecules Letter, 2015, 4(3): 339-342
[18] Zhi Yuan*, Shieldable Tumor Targeting Based on pH-Responsive Self-Assembly/Disassembly of Gold Nanoparticles, ACS Applied Materials & Interfaces, 2014, 6(20), 17865–17876
[19] Zhi Yuan*, Study on the efficiency and interaction mechanism of a decapeptide inhibitor of β-amyloid aggregation, Biomacromolecules. 2014, 15(3):931-939
[20] Zhi Yuan*, Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy, Biomaterials, 2012, 33(7): 2187–2196
[21] Zhi Yuan*, A New Method for Affinity Adsorbent Screening Using Gold Colloids, Langmuir, 2011, 27(18):11457–11465
[22] Zhi Yuan*, Novel Silk Fibroin/Montmorillonite Nanocomposites: Effect of pH on the Conformational Transition and Clay Dispersion, Biomacromolecules, 2010, 11(7):1796–1801
[23] Zhi Yuan*, Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(γ-benzyl L-glutamate) micelles for liver targeting therapy, Acta Biomaterialia, 2010, 6(10):3927-3935
[24] Zhi Yuan*, Glycyrrhetinic acid-modified chitosan / poly(ethylene glycol) nanoparticles for liver-targeted delivery, Biomaterials, 2010, 31:4748-56
[25] Zhi Yuan*, Adsorption mechanism at the molecular level between polymers and uremic octapeptide by 2D 1H NMR technique,Biomacromolecules,2006, 7(6):1811-1818
[26] Zhi Yuan* , Endotoxin adsorbent using dimethylamine ligands, Biomaterials, 2005,26(15):2741-2747

Professional Cultivation

21 postgraduates and 23 PhD students have been got their degree in Yuan's group.