Address: Insititute of Polymer Science, Nankai University, 300071 

Telephone:

1998-2001 Beijing Normal University, Bachelor;
2000-2003 Tianjin Normal University, Master;
2003-2006 Nankai Univeristy, Ph.D;
2006- Nankai University, Associate Professor.
2013-2014，University of Washington(Seattle), Research associate
 

Research interests include the design and synthesis of functional polymers based on pathological features of certain diseases and clinical trial applications, unique macromolecular architectures and complex polymer assemblies, and the design and development of well-defined nanostructured materials. The development of novel synthetic strategies, fundamental study of the materials’ properties, and their applications for the diagnosis and treatment of disease, for performance as non-toxic anti-bacterial nanoscale materials, are particular foci of her research activities. She has published 1 patent and 57 papers on international journals such as Biomaterials, Journal of Controlled Release, Biomacromolecules, Acta Biomaterialia, Polymer Chemistry, Journal of Materials Chemistry, ACS Applied Materials Interfaces, etc. She is the editorial member of ISRN Medicinal Chemistry and serves as a reviewer for Accounts of Chemical Research, Chemical Reviews, Advanced Materials, Advanced Functional Materials, Biomaterials, Biomacromolecules, Molecular Pharmaceutics, Nanomedicine-UK, ACS Applied Materials Interfaces, Nanoscale, and so forth.

Publications:
1.Qianqian Guo, Yu Zhao, Xiaomei Dai, Tianqi Zhang, Yunjian Yu, Xinge Zhang,* Chaoxing Li*. Functional silver nanocomposites as broad-spectrum antimicrobial and biofilm-disrupting agents. ACS Appl. Mater. Interfaces, 2017, 9 (20):16834-16847.
2.Xiaomei Dai, Xuelei Chen, Jing Zhao, Yu Zhao, Qianqian Guo, Tianqi Zhang, Chunli Chu, Xinge Zhang*, Chaoxing Li. Structure activity relationship of membrane-targeting cationic ligands on a silver nanoparticle surface in an antibiotic-resistant antibacterial and antibiofilm activity assay. ACS Appl. Mater. Interfaces, 2017, 9 (16):13837-13848.
3. Xiaomei Dai, Yu Zhao, Yunjian Yu, Xuelei Chen, Xiaosong Wei, Xinge Zhang*, Chaoxing Li. Single continuous near-infrared laser-triggered photodynamic and photothermal ablation of antibiotic-resistant bacteria using effective targeted copper sulfide nanoclusters. ACS Appl. Mater. Interfaces, 2017, 9 (16):30470-30479.
4.Xiaomei Dai, Xuelei Chen, Yu Zhao, Yunjian Yu, Xiaosong Wei, Xinge Zhang*, Chaoxing Li
A water-soluble galactose-decorated cationic photodynamic therapy agent based on BODIPY to selectively eliminate biofilm. Biomacromolecules, 2017, accepted.
5.Jinxia An, Qianqian Guo, Peng Zhang, Andrew Sinclair, Xinge Zhang*, Kan Wu, Fang Sun, Hsiang-Chieh Huang, Chaoxing Li, Shaoyi Jiang*. Hierarchical design of a polymeric nanovehicle for efficient tumor regression and imaging. Nanoscale, 2016, 8(17):9318-9327.
6.Xiaomei Dai, Qianqian Guo, Jinxia An, Peng Zhang, Yu Zhao, Tianqi Zhang, Xinge Zhang*, Chaoxing Li. Functional silver nanoparticles as the benign antimicrobial agents against multi-drug resistant bacteria. ACS Appl. Mater. Interfaces, 2016, 8:25798-25807.
7.Zhentan Lu, Xinge Zhang*, Yu Zhao, Yinan Xue, Zhai Tingting, Zhongming Wu, Chaoxing Li. BODIPY-based macromolecular photosensitizer with cation enhanced antibacterial activity. Polymer Chemistry, 2015, 6:302-310.
8.Zhentan Lu, Xinge Zhang*, Zhongyu Li, Zhongming Wu, Jia Song, Chaoxing Li*. Composite copolymers hybrid silver nanoparticles: Preparation and characterization of antibacterial activity and cytotoxicity. Polymer Chemistry, 2015, 6:772-779.
9.Qianqian Guo, Tianqi Zhang, Jinxia An, Zhongming Wu, Yu Zhao, Xiaomei Dai, Xinge Zhang*, Chaoxing Li*. Block versus random amphiphilic glycopolymer nanoparticles as glucose-responsive vehicles. Biomacromolecules 2015, 16:3345-3356.
10.Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang*, Chaoxing Li*. A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells. Polymer Chemistry, 2015, 6:6529-6542.
11.Jinxia An, Xiaomei Dai, Zhongming Wu, Yu Zhao, Zhentan Lu, Qianqian Guo, Xinge Zhang*, Chaoxing Li. An acid-triggered degradable and fluorescent nanoscale drug delivery system with enhanced cytotoxicity to cancer cells. Biomacromolecules, 2015, 16 (8):2444-2454.
12.Lei Sun, Xinge Zhang*, Zhongming Wu, Chao Zheng, Chaoxing Li*. Oral glucose- and pH-sensitive nanocarriers for simulating insulin release in vivo. Polymer Chemistry. 2014, 5: 1999-2009.
13.Qianqian Guo, Zhongming Wu, Xinge Zhang*, Lei Sun, and Chaoxing Li. Phenylboronate-diol crosslinked glycopolymeric nanocarriers for insulin delivery at physiological pH. Soft Matter, 2014,10:911-920.
14.Lin Mei, Xinge Zhang*, Yanan Wang, Zhentan Lu, Yu Zhao, Chaoxing Li. Multivalent gold nanoparticles with cationic surfaces displaying enhanced antimicrobial activity. Polymer Chemistry, 2014, 5(8):3038-3044.
15.Yanxia Wang, Xinge Zhang*, Chaoxing Li. Mucoadhesive and enzymatic inhibitory nanoparticles for transmucosal insulin delivery. Nanomedicine, 2014, 9(4):451-464.
16.Lin Mei, Zhentan Lu, Xinge Zhang*, Chaoxing Li*, Yanxia Jia. Polymer-Ag nanocomposites with enhanced antimicrobial activity against bacterial infection. ACS Appl. Mater. Interfaces, 2014, 6(18):15813-15821.
17.Zhentan Lu, Xinge Zhang*, Lin Mei, and Chaoxing Li*. Highly water-soluble, multivalent and target-specific BODIPY-conjugated glycopolymers for living cells. Polymer Chemistry, 2013,4:5743-5750.
18.Lin Mei, Wei Zhang, Zhentan Lu, Xinge Zhang*, Yanan Wang, Yuting Luo, Chaoxing Li*, Zhongming Wu, Yanxia Jia. Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria. Biomaterials, 2013, 34(38):10328–10337.
19.Cui Cheng, Xinge Zhang*, Yanxia Wang, Chao Zheng, Zhentan Lu, Chaoxing Li*. Development of novel self-assembled poly(3-acrylamidophenylboronic acid)/ poly(2-lactobionamidoethyl methacrylate) hydrid nanoparticles for improving nasal adsorption of insulin. Soft Matter, 2012, 8:765-773.
20.Zhongming Wu, Xinge Zhang*, Gonglei Guo, Chaoxing Li,Demin Yu. An injectable and glucose-sensitive nanogel for controlled insulin release. Journal of Material Chemistry, 2012, 22:22788-22796.
21.Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li*, Zhen Wang. A novel hydrotropic β-cyclodextrin grafted hyperbranched polyglycerol copolymer for hydrophobic drug delivery. Acta Biomaterialia, 2011,7:585-592.
22.Shujun Shu, Chunyang Sun, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery. Acta Biomaterialia, 2010, 6:210-217.
23.Shujun Shu, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery. Biomaterials, 2010,31(23):6039-6049.
24.Xingju Jin, Xinge Zhang*, Zhongmin Wu, Dayong Teng, Xuejiao Zhang, Yanxia Wang, Zhen Wang, Chaoxing Li*. Amphiphilic random glycopolymer based on phenylboronic acid: Synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules, 2009, 10:1337-1345.
25.Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li*. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery. Journal of Controlled Release, 2009, 140:141-147.
 

PhD students
Zhang Xinge Nankai University
Tang Yu Tianjin Tasly pharmaceutical Limited Company
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Teng Dayong
Gao Xiujun Tianjin Medical University
Shu Shujun The Dow Chemical Company
Cheng Cui Fuzhou University
Wang Yanxia
Mei Lin Zhongyuan University of Technology
Sun Lei
Lu Zhentan Wuhan Textile University

Master's students
Zhang Huijie
Li Bo
Niu Haimei
Hou Jinli Tianjin Medical University
Zheng Chao
Jin Xingju Guang zhou Human Chemistry
Zhang Xuejiao
Xiang Jixin Tianjin Salt Bureau
Han Yucai
Yu Peien
Wang Yanan