Synthesis of Natural Products


    Prof. Jianhua Xie has developed several highly efficient catalytic asymmetric hydrogenation of ketones with chiral spiro ruthenium and iridium catalysts for the synthesis of chiral alcohols with contiguous stereocenters. Using these highly efficient methods several bioactive natural products including ()-galanthamine, ()-hapalindole Q, ()-gracilamine, ()-goniomitine, and mulinane-type diterpenoids were synthesized in a concise and/or divergent fashion with high efficiency and enantioselectivity.