Prof. Shou-Fei Zhu’s group interests in the development of advanced synthetic methodology as well as synthetic theory through developing catalysts and reactions. Their studies mainly focus on catalytic organic synthesis, particularly those involving hydrogen transfer as key steps. They proposed the concept of chiral proton shuttle catalyst, which realized a variety of challenging asymmetric proton transfer reactions. They developed a catalytic B-H bond insertion reaction, which provides a new opportunity for the structural diversity synthesis of or ganic boron. They also developed a variety of new catalysts for hydride transfer reactions, which improved synthetic efficiency of many pharmaceuticals. The above findings have inspired numbers follow-up researches and been used in the production of chiral drugs by well-known pharmaceutical companies.